Outperforming Completely Randomized Designs

Nonparametric Tests for Ordering in Completely Randomized and Randomized Block Mixed Designs

Two nonparametric tests are proposed in testing for k nondecreasing treatment effects under a mixed design consisting of a completely randomized portion and a randomized block portion. The randomized block portion may contain missing observations for some of the treatments within a block. A simulation study is conducted to estimate the powers of the two tests for 3, 4, and 5 treatments under a ...

Completely Regular Designs of Strength One

We study a class of highly regular t-designs. These are the subsets of vertices of the Johnson graph which are completely regular in the sense of Delsarte [2]. In [9], Meyerowitz classified the completely regular designs having strength zero. In this paper, we determine the completely regular designs having strength one and minimum distance at least two. The approach taken here utilizes the inc...

Efficient Randomized - Adaptive Designs

Response-adaptive randomization has recently attracted a lot of attention in the literature. In this paper, we propose a new and simple family of response-adaptive randomization procedures that attain the Cramer–Rao lower bounds on the allocation variances for any allocation proportions, including optimal allocation proportions. The allocation probability functions of proposed procedures are di...

Randomized phase II designs.

As the use of molecularly targeted agents, which are anticipated to increase overall survival (OS)and progression-free survival (PFS) but not necessarily tumor response, has increased in oncology, there has been a corresponding increase in the recommendation and use of randomized phase II designs. Such designs reduce the potential for bias, existent in comparisons with historical controls, but ...

Randomized Experiments and Quasi - Experimental Designs 5 RANDOMIZED EXPERIMENTS AND QUASI - EXPERIMENTAL DESIGNS IN EDUCATIONAL RESEARCH